Tolerance to self antibodies?

Ok, so in class we are talking about how mouse derived antibodies cannot be therapeutically used in humans because they are foreign. Instead, we can use recombinant DNA to produce an antibody that contains the V region from a mouse and the C region from a human. He says that this hybrid antibody is still... show more Ok, so in class we are talking about how mouse derived antibodies cannot be therapeutically used in humans because they are foreign. Instead, we can use recombinant DNA to produce an antibody that contains the V region from a mouse and the C region from a human. He says that this hybrid antibody is still immunogenic because of the mouse V region, but not as much as an antibody that is entirely mouse derived.

My question is, if our immune systems are capable of mounting a response to variable regions on Ab, how do we not produce immune responses to our own variable regions. Are all our antibodies tolerated against all the endless combinations of our other antibodies...That seems unlikely? How does this work?
Update: I understand that lymphocytes are eliminated that attack self antigens, but are all lymphocytes tolerated against all other antibodies out body produces?
1 answer 1