Risk vs. Consequence
That is the main argument. What is the risk with taking the medication? What is the risk with not taking the medications? What are the consequences?
As a pharmacist, I have seen patients with as much as 20 medications. Depends on the health issues the person has: Asthma, diabetes, high blood pressure, high cholesterol, etc.
There are no magical cures and most long-term diseases can only be "controlled." It use that term loosely. Most medications just alleviate effects of the diseases. However, there is no perfect drug and they all have side effects.
Lovastatin helps to lower cholesterol, but an cause muscle pain. Omeprazole helps to lower stomach acid, but can cause bleeding. Ibuprofen is used to lower inflammation and pain, but can increase blood pressure.
Don't forget the extra medications taken just to combat the side effects of the other medications.
Ask yourself: "What are the risks and the consequences?"
As stated by others, you can try a healthy lifestyle and diet. However, sometimes that is not enough.